The implementation of a Manufacturing Execution System (MES) in Research and Development (R&D) for Drug Product and Device (DV) manufacturing is crucial for enhancing operational efficiency, ensuring compliance, and improving product quality. This presentation explores the deployment and current operational status of the Werum PAS-X MES within an R&D environment (Clinical Manufacturing in Schaffhausen) . The Werum PAS-X system offers comprehensive functionalities tailored to the pharmaceutical industry, including electronic batch recording, real-time monitoring, and data integrity assurance. By integrating PAS-X, R&D facilities can streamline processes, reduce manual interventions, and achieve higher levels of traceability and transparency. The presentation highlights key implementation strategies, challenges encountered, and the benefits realized, such as improved process control, reduced cycle times, and enhanced regulatory compliance.