This presentation initiates the journey towards smart factory status by outlining the foundational steps required for seamless integration of Manufacturing Execution Systems (MES) with other Operational Technology (OT) and Information Technology (IT) systems. Delve into critical considerations such as quality assurance, scheduling optimization, network infrastructure, robust backup protocols, cybersecurity measures, and compliance with regulatory standards like CSV (Computer System Validation). Explore cutting-edge technologies driving GMP (Good Manufacturing Practice) IT-OT systems, empowering factories to achieve heightened operational efficiency and regulatory compliance.